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Title   국한성 진행 두경부 악성종양 ( 편평 상피암 ) 에 대한 선행 화학요법 및 방사선요법의 병용치료 효과 ( Neadjuvant Chemotherapy with 5-Fluorouracil Infusion and Cisplatin Followed by Radiotherapy for Locally Advanced Head and Neck Cancer )
Publicationinfo   1988 Jan; 020(01): 82-90.
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Abstract   Thirty-two patients with previously untreated, locally advanced squamous cell carcinoma of the head and neck were treated with 2 or 3 cycles of combination chemotherapy consisting of 5- fluorouracil infusion and cisplatin (FP), followed by curative radiotherapy. Three patients(9%) achieved complete respanses and 25(78%), partial responses after neaadjuvant chemotherapy. Follow- ing subsequent radiotherapy, 16(50%) achieved complete responses and 14(44%), partial responses, giving overall response rate of 94% with a median duration of response of 24.0+ and 9.5 months, respectively. The median survivals of the patients with complete and partial responses were 24.0+ and 11.0 months, respectively. The median survival of the patients with complete responses were significantly prolonged in comparison with that of those with partial responses. Toxicities from the treatments were common, but most of which were easily manageable and transient, with no treatment-related fatalities.
저 자   방영주(Yung Jue Bang),윤성수(Sung Soo Yoon),박근칠(Keun Chil Park),이재훈(Jae Hoon Lee),김승택(Seung Taek Kim),김노경(Noe Kyeong Kim),박찬일(Charn Il Park),김광현(Kwang Hyun Kim),민양기(Yang Gi Min)